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The Spine and Trauma Biologics and Biomaterials portfolio includes the FIBERGRAFT™ Bioactive Glass , PliaFX™ Prime, FIBERGRAFT™ AERIDYAN™ Matrix, and the ViviGen™ Cellular Bone Matrix 19-21,25.
Featured Products
FIBERGRAFT™ AERIDYAN™ Matrix
FIBERGRAFT™ AERIDYAN™ Matrix is the first bone graft substitute that contains boron-based bioactive glass with essential elements (magnesium, zinc, copper, and potassium)21,22,**. FIBERGRAFT™ AERIDYAN™ Matrix is an osteoconductive, resorbable, bioactive bone graft substitute21,23,24,**.
FIBERGRAFT™ Bioactive Glass
FIBERGRAFT™ Bioactive Glass creates a scaffold that provides direct connectivity, high surface area, continuous porosity, and resorption rates consistent with bone formation4,25,**.
PliaFX™ Prime
PliaFX™ Prime is 100% bone fibers that have been demineralized to encourage bone formation and healing. The fibers interlock, allowing the graft to become moldable upon rehydration without the use of a carrier6-19*.
ViviGen™ Cellular Bone Matrix
ViviGen™ Cellular Bone Matrix is a cellular allograft focused on lineage committed bone-forming cells. It contains all the properties necessary for bone formation20*.
FIBERGRAFT™ AERIDYAN™ Matrix
FIBERGRAFT™ AERIDYAN™ Matrix is the first bone graft substitute that contains boron-based bioactive glass with essential elements (magnesium, zinc, copper, and potassium)21,22,**. FIBERGRAFT™ AERIDYAN™ Matrix is an osteoconductive, resorbable, bioactive bone graft substitute21,23,24,**.
FIBERGRAFT™ Bioactive Glass
FIBERGRAFT™ Bioactive Glass creates a scaffold that provides direct connectivity, high surface area, continuous porosity, and resorption rates consistent with bone formation4,25,**.
PliaFX™ Prime
PliaFX™ Prime is 100% bone fibers that have been demineralized to encourage bone formation and healing. The fibers interlock, allowing the graft to become moldable upon rehydration without the use of a carrier6-19*.
ViviGen™ Cellular Bone Matrix
ViviGen™ Cellular Bone Matrix is a cellular allograft focused on lineage committed bone-forming cells. It contains all the properties necessary for bone formation20*.
FIBERGRAFT™ AERIDYAN™ Matrix
FIBERGRAFT™ AERIDYAN™ Matrix is the first bone graft substitute that contains boron-based bioactive glass with essential elements (magnesium, zinc, copper, and potassium)21,22,**. FIBERGRAFT™ AERIDYAN™ Matrix is an osteoconductive, resorbable, bioactive bone graft substitute21,23,24,**.
FIBERGRAFT™ Bioactive Glass
FIBERGRAFT™ Bioactive Glass creates a scaffold that provides direct connectivity, high surface area, continuous porosity, and resorption rates consistent with bone formation4,25,**.
PliaFX™ Prime
PliaFX™ Prime is 100% bone fibers that have been demineralized to encourage bone formation and healing. The fibers interlock, allowing the graft to become moldable upon rehydration without the use of a carrier6-19*.
ViviGen™ Cellular Bone Matrix
ViviGen™ Cellular Bone Matrix is a cellular allograft focused on lineage committed bone-forming cells. It contains all the properties necessary for bone formation20*.
FIBERGRAFT™ AERIDYAN™ Matrix
FIBERGRAFT™ AERIDYAN™ Matrix is the first bone graft substitute that contains boron-based bioactive glass with essential elements (magnesium, zinc, copper, and potassium)21,22,**. FIBERGRAFT™ AERIDYAN™ Matrix is an osteoconductive, resorbable, bioactive bone graft substitute21,23,24,**.
FIBERGRAFT™ Bioactive Glass
FIBERGRAFT™ Bioactive Glass creates a scaffold that provides direct connectivity, high surface area, continuous porosity, and resorption rates consistent with bone formation4,25,**.
PliaFX™ Prime
PliaFX™ Prime is 100% bone fibers that have been demineralized to encourage bone formation and healing. The fibers interlock, allowing the graft to become moldable upon rehydration without the use of a carrier6-19*.
ViviGen™ Cellular Bone Matrix
ViviGen™ Cellular Bone Matrix is a cellular allograft focused on lineage committed bone-forming cells. It contains all the properties necessary for bone formation20*.
FIBERGRAFT™ AERIDYAN™ Matrix
FIBERGRAFT™ AERIDYAN™ Matrix is the first bone graft substitute that contains boron-based bioactive glass with essential elements (magnesium, zinc, copper, and potassium)21,22,**. FIBERGRAFT™ AERIDYAN™ Matrix is an osteoconductive, resorbable, bioactive bone graft substitute21,23,24,**.
FIBERGRAFT™ Bioactive Glass
FIBERGRAFT™ Bioactive Glass creates a scaffold that provides direct connectivity, high surface area, continuous porosity, and resorption rates consistent with bone formation4,25,**.
PliaFX™ Prime
PliaFX™ Prime is 100% bone fibers that have been demineralized to encourage bone formation and healing. The fibers interlock, allowing the graft to become moldable upon rehydration without the use of a carrier6-19*.
ViviGen™ Cellular Bone Matrix
ViviGen™ Cellular Bone Matrix is a cellular allograft focused on lineage committed bone-forming cells. It contains all the properties necessary for bone formation20*.
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References
* Pre-clinical test data/results may not necessarily be indicative of human clinical performance (or outcomes).
** Pre-clinical test data are not necessarily indicative of clinical performance.
- Stryker® Biologics Product Catalog Copyright© 2015 Stryker.
- Cerapedics. i-FACTOR™ Peptide Enhanced Bone Graft. IFU.
- 510(k) Summary. NovaBone Putty - Bioactive Synthetic Graft. 2007. K080009.
- Prosidyan. BG Morsels Characterization. 2018.SR0002
- Bohner M, Santoni BLG, Döbelin N. β-tricalcium phosphate for bone substitution: Synthesis and properties. Acta Biomater. 2020;113:23-41.
- Kay, JF, Vaughan LM. Proportional osteoinduction of demineralized bone matrix graft materials. February 2004: AW-0204.1.
- J. B. McLean, N. Carter, P. Sohoni, and M. A. Moore, ‘Cell Attachment and Osteoinductive Properties of Tissue Engineered, Demineralized Bone Fibers for Bone Void Filling Applications’, Clinical Implementation of Bone Regeneration and Maintenance. IntechOpen, Feb. 10, 2021.
- Gruskin E, Doll BA, Futrell FW, et al. Demineralized bone matrix in bone repair: History and use. Advanced Drug Delivery Reviews. 2012; 64: 1063-1077.
- LifeNet Health. Rehydration and irrigation characterization for moldable demineralized fibers. LifeNet Health #ES-17-090.
- LifeNet Health. LifeNet Health #ES-17-090.
- Murphy MB, Suzuki RK, Sand TT, et al. Short Term Culture of Human Mesenchymal Stem Cells with Commercial Osteoconductive Carriers Provides Unique Insights into Biocompatibility. J Clin. Med. 2013; 2: 49-66.
- Sampson, Alana. Addendum: Interaction of Cells with Moldable Demineralized Fibers. 6/8/2018. LifeNet Health Document #ES-17-111-02.
- Zhang M, Powers RM, and Wolfinbarger L. Effect(s) of the Demineralization Process on the Osteoinductivity of Demineralized Bone Matrix. J Periodontol. 1997; 68: 1085-1092.
- Turonis JW, McPherson JC 3rd, Cuenin MF, et al. The Effect of Residual Calcium in Decalcified Freeze-dried Bone Allograft in a Critical-sized Defect in the Rattus norvegicus Calvarium. J Oral Implantol. 2006; 32(2): 55-62.
- Herold RW, Pashley DH, Cuenin MF, et al. The Effects of Varying Degrees of Allograft Decalcification on Cultured Porcine Osteoclast Cells. J Periodontol. 2002; 73(2): 213-219.
- Pietrzak WS, Ali SN, Chitturi D, Jacob M, Woodell-May JE. BMP depletion occurs during prolonged acid demineralization of bone: characterization and implications for graft preparation. Cell Tiss. Bank. 29 December 2009 (Published online).
- Cornell CN, Lane JM. Current Understanding of Osteoconduction in Bone Regeneration. Clin Orthop and Relat Res. 1998; 355 Suppl: S267-S273.
- LifeNet Health, PliaFX® Pak – Moldable Demineralized Fibers White Paper. 2022. 68-20-369.00
- LifeNet Health. PliaFX™ Prime Scientific Summary Advantage of 100% Bone. 2020. 68-20-297.00
- Gianulis E, Wetzell B, Scheunemann D, et al. Characterization of an advanced viable bone allograft with preserved native bone-forming cells. Cell Tissue Bank. 2023; 24(2): 417-434.
- Prosidyan. Characterization of Boron Microspheres (MS-B) 2018. SR0078.
- JNJ Basil Systems. https:__jnj.basilsys.com_medical device_results?application_type=510k&query=boron%20bioactive%20glass. [Accessed 25 August 2023].
- Prosidyan, In-vivo Evaluation of FIBERGRAFT AERIDYAN Matrix in a Critical Size Defect Model in New Zealand White Rabbits,2022, SR0139.
- Prosidyan,510(k) K182670, FIBERGRAFT AERIDYAN Matrix Bone Graft Substitute, 2018.
Prosidyan.BG Morsels Sheep Study Pathology Report.2018.SR0012.
Important Information: Prior to use, refer to the instructions for use supplied with the device(s) for indications, contraindications, side effects, warnings and precautions.
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